General

The general involvement of the endocannabinoid system in cancer development mechanisms is a fascinating and promising research topic. The endocannabinoid system, made up of endogenous receptors and ligands, plays a key role in maintaining the body's homeostatic balance.

Studies have shown that this system also participates in the regulation of cell proliferation, angiogenesis and apoptosis, processes involved in the development of cancer. Additionally, substances such as CBD and THC, found in the cannabis plant, have demonstrated potential antitumor properties by targeting these endocannabinoid receptors.

However, further research is needed to better understand the underlying mechanisms and fully exploit the therapeutic potential of the endocannabinoid system in the fight against cancer.

Lung

The endocannabinoid system plays a fundamental role in the mechanisms of action of lung cancer. Cannabinoids, such as THC and CBD, bind to CB1 and CB2 receptors present in cancer cells, resulting in a cascade of intracellular reactions.

This interaction causes the activation of signaling pathways which inhibit the proliferation of tumor cells and induce their programmed death, apoptosis. In addition, the endocannabinoid system also exerts an anti-angiogenic effect, preventing the formation of new blood vessels essential for tumor growth.

In addition, cannabinoids have been shown to stimulate the immune system and promote the elimination of cancer cells by cells of the immune system. These discoveries offer promising new perspectives for the development of targeted therapies against lung cancer.

Breast

The endocannabinoid system, a complex network of receptors and signaling molecules, has been found to play a significant role in the development and progression of breast cancer. The system exerts its effects through a series of mechanisms. Firstly, the activation of cannabinoid receptors, namely CB1 and CB2, can induce cell death and inhibit the growth of cancer cells.

Additionally, the endocannabinoid system can modulate the tumor microenvironment by reducing inflammation and promoting anti-tumor immune responses. Moreover, it has been shown to inhibit angiogenesis, the formation of new blood vessels that supply nutrients to tumors. Furthermore, the endocannabinoid system can regulate metastasis, the spread of cancer cells to distant organs.

These mechanisms highlight the potential therapeutic value of targeting the endocannabinoid system in the treatment of breast cancer.